Organic Mass Spectrometry
The Organic Mass Spectrometry Department at ORS provides method development and mass spectrometry testing services to a variety of industries. GC/MS analysis can be performed on a variety of sample matrices via Static Headspace, IVA® of hermetic devices, solvent extraction and direct injection, direct air injection, residual solvent analysis, gas cylinder analysis, and analysis of samples placed in ampules. Testing is qualitative, semi-quantitative, and can be customized to suit your analytical needs. Testing capabilities and a partial list of applications are presented below.
- Gas Chromatography/Mass Spectrometry (GC/MS): Common applications include contamination identification, purity determination and identification of “unknown” compounds in bulk organics.
- Internal Vapor Analysis™/ Gas Chromatography/Mass Spectrometry (IVA®/GC/MS): Used for the analysis of organic constituents in the headspace of hermetic packages and ampoules; Identification of volatile and semi-volatile organics.
- Static Head Space/Gas Chromatography/Mass Spectrometry: A technique useful for the analysis of volatile and semi-volatile organics off-gassing from low concentration components in bulk materials, including solid and liquid matrices.
- Direct Air Injection/Residual Solvent Analysis/Gas Cylinder Analysis/Gas Chromatography/Mass spectrometry: Used to analyze components of gas phase samples for volatile and semi-volatile organics. Uses Liquid N2 cryofocus for improved chromatography. Samples can be whole air samples collected in gas sampling cylinders provided by ORS, pharmaceutical products in hermetic packages, or other suitable containers containing gaseous samples.
MEL-1080: Identification of UNKNOWN volatile and semi-volatile organic compounds by IVA®/GC/MS
This test method is used to identify unknown organic compounds that may be detected by IVA® test methods but may not be conclusively identified due to the complexity or trace quantity of the mass spectra. Standard hermetic devices, gas cylinders or individual materials sealed in glass ampules may be analyzed. The technique is useful to understand the trace contaminants, chemical processes of material outgassing and chemical reactions from environmental stress for:
- Time/Temperature Preconditioning
- Variable Test Temperature (up to 1100°C)
- Adjustable AMU Scan Range and Speed
- Variable Data Acquisition Time
- Flexibility in Sample Puncture Location
The Format of GC/MS IVA®Results
- Semi-Quantitative Results
- Discussion and Summary of analysis
- Tentatively Identified Compounds (TIC) Summary page using NIST’11 Mass Spectral Database (>243,000 spectra)
- Estimated Concentrations and Chemical Abstract Services (CAS) #’s
- Chromatograms and overlays of Chromatograms and Control samples highlighting areas of interest
- Individual peak mass spectra available
- Customized report formats available. Call to discuss options.
- GC/MS Standard Sample Report
GC/MS Test Capabilities
- PPB range sensitivity
- Typical amu range 35-550. Instrument capability of 1.6 to 1050 amu
- Customized instrument temperature programs
- Scan, SIM (Select Ion Monitoring), and synchronous SIM/Scan capability
- Negative EI (electron impact)
- Flexibility in sample holding temperature during analysis
- Flexibility in sample pre-bake times
- Flexibility in test protocol
Gas Analysis Services Customized to Fit Your Needs
Our experienced technical staff is available to discuss your specific application and recommend a test plan that will fit your individual needs. 1 (855) ORS LABS